Currently I am reading „Lifespan: Why We Age – And Why We Don’t Have To“ by David Sinclair, and I stumbled upon the following paragraph:

But what about FOXO genes in humans? Certain variants called FOXO3 have been found in human communities in which people are known to enjoy both longer lifespans and healthspans, such as the people of China’s Red River Basin. These FOXO3 variants likely turn on the body’s defenses against diseases and aging, not just when times are tough but throughout life. If you’ve had your genome analyzed, you can check if you have any of the known variations of FOXO3 that are associated with a long life. For example, having a C instead of a T variant at position rs2764264 is associated with longer life. Two of our children, Alex and Natalie, inherited two Cs at this position, one from Sandra and one from me, so all other genes being equal, and as long as they don’t live terribly negative lifestyles, they should have greater odds of reaching age 95 than I do, with my one C and one T, and substantially greater than someone with two Ts.

„Lifespan: Why We Age – And Why We Don’t Have To“ by David Sinclair

Last year I already sequenced my DNA and built a dedicated tool to analyze my own raw genetic data. Using that tool, I confirmed that I share exactly this variation mentioned in the paragraph.

This tool was meant to investigate build relations between SNP, Genes and Illnesses/Traits using scientific evidence. Often this relation is not easy to make. Here, such a use case is demonstrated.